Casual exercise and creative thought can lessen neurological disease severity by half. Experimental evidence shows that the mechanisms by which such naturally occurring enrichment reduces destructive injury of brain involves increased production of insulin-like growth factor-1 (IGF-1). Seurat Therapeutics posited that IGF-1 might also be effective, like enrichment, against disorders that involve aberrant excitability of the brain similar to that seen with migraine as well as, chronic pain including fibromyalgia and epilepsy.